论文标题：Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes

期刊：Microsystems&Nanoengineering

作者：Bowen Ji, Zhejun Guo, Minghao Wang, Bin Yang, Xiaolin Wang, Wen Li, Jingquan Liu

发表时间：2018/10/08

数字识别码： 10.1038/s41378-018-0027-0

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明升中国上海交通大学Jingquan Liu等研究成果：

app家们最近研究出了一种可以植入在大鼠大脑中的柔性器件，这种器件可通过光线精确地打开大鼠的神经细胞并同步记录它们的活动，而且比较耐用。明升中国上海交通大学的Jingquan Liu等研究者将稳定的引线键合型微LED和改良的微电极阵列结合起来，设计出这种新型的器件，能够比目前在光遗传学中使用的光纤更精确地定位到局部大脑皮层。在这领域的研究中，app家们是通过基因改变神经细胞来产生光敏蛋白质，从而让他们能通过光线来控制神经活动。该研究对于治疗帕金森病和抑郁症等疾病的有所帮助。经过3个月的浸泡测试，反复按压摩擦5000次，新设备仍保持着良好的性能。这是一种在多功能光遗传领域很有用的工具，并且可能和无线技术进行集成在一起，具有较好的前景。

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A durable, flexible device can be implanted on rat brains to precisely turn on nerve cells using light and synchronously record their activities. Jingquan Liu and colleagues from Shanghai Jiao Tong University in China combined reliable wire-bonding micro-LED and modified microelectrode arrays to design a device that can more precisely target local brain cortex with light than the currently used optic fibers in optogenetics. In this field of research, scientists genetically alter nerve cells to produce light-sensing proteins, allowing them to control nerve activity with light. This could lead to advancements in the treatment of diseases like Parkinson’s and depression. The new device retains good performance after 3 months of soaking test and repeated pressing and friction for 5000 times. It is a useful multifunctional optogenetics tool and potentially integrated with wireless technology.

摘要：In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrOx-modified microelectrodes for synchronous photostimulation and neural signal recording is presented. The 4 × 4 micro-LEDs (dimensions of 220 × 270 × 50 μm3, 700 μm pitch) are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method. The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites (200 μm in diameter and 700 μm in pitch) modified by iridium oxide (IrOx). These two subparts can be aligned with alignment holes and glued back-to-back by epoxy, which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites. The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months, and the thermal property is specifically studied with different duty cycles, voltages, and frequencies. Additionally, the electrochemical results prove the reliability of the IrOx-modified microelectrodes after repeated pressing or friction. To evaluate the tradeoff between flexibility and strength, two microelectrode arrays with thicknesses of 5 and 10 μm are evaluated through simulation and experiment. The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small (rats and mice) and large animal subjects and ultimately in nonhuman primates.

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期刊介绍： Microsystems & Nanoengineering is an online-only, open access international journal devoted to publishing original research results and reviews on all aspects of Micro and Nano Electro Mechanical Systems from fundamental to applied research. The journal is published by Springer Nature in partnership with the Institute of Electronics, Chinese Academy of Sciences, supported by the State Key Laboratory of Transducer Technology.

（来源：明升手机版(明升中国)）