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PAC | Protein & Cell 最新文章欢迎阅览 |
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论文标题：Protein & Cell Issue 10 of 2022 is released!
期刊：
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COVER STORY: Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies for improving the efficiency of germ cell production in vitro. Shi et al. developed a coupled screening strategy that took advantage of an arrayed BiFC platform for protein-protein interaction screens and EpiLC-induction assays using reporter mESCs. Investigation of candidate interaction partners of core human pluripotent factors OCT4, NANOG, KLF4 and SOX2 in EpiLC differentiation assays identified novel primordial germ cell (PGC)-inducing factors including BEN-domain (BEND/ Bend) family members. Through RNA-seq, ChIP-seq, and ATAC-seq analyses, the authors showed that Bend5 worked together with Bend4 and helped mark chromatin boundaries to promote EpiLC induction in vitro. These suggest that BEND/Bend proteins represent a new family of transcriptional modulators and chromatin boundary factors that participate in gene expression regulation during early germline development.
Recollection
Yong Wang, Wei Chen, Shiying Li, Bin Yin
Review
Peng Yin, Shihua Li, Xiao-Jiang Li, Weili Yang
Research Articles
Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang
Yuting Wang, Liping Liu, Yifan Song, Xiaojie Yu, Hongkui Deng
Linhua Tai, Yun Zhu, He Ren, Xiaojun Huang, Chuanmao Zhang, Fei Sun
Contact us: protein_cell@mail.biols.ac.cn
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