论文标题：Lower Incidence Rate of Type 1 Diabetes after Receipt of the Rotavirus Vaccine in the United States, 2001–2017

期刊：

作者：Mary A. M. Rogers, Tanima Basu, Catherine Kim

发表时间：2019/06/13

数字识别码： 10.1038/s41598-019-44193-4

原文链接：

微信链接：

根据《app手机版》发表的一项研究 Lower Incidence Rate of Type 1 Diabetes after Receipt of the Rotavirus Vaccine in the United States, 2001–2017，常规接种轮状病毒疫苗可能和儿童I型糖尿病风险降低相关。轮状病毒是腹泻和呕吐的一种常见起因。

图1：研究参与者的流程图。图源：Rogers

美国密歇根大学安娜堡分校的Mary Rogers及同事利用来自私人健康保险公司的匿名数据，研究了2001年至2017年在美国出生的1,474,535名婴儿，发现完全完成轮状病毒疫苗接种（即接种了所有必需剂量）的儿童与未接种的儿童相比，前者I型糖尿病的风险有所下降。在2006年至2017年间出生且接种了疫苗的540,317名儿童中，192名患上了糖尿病（相当于每年12.2/十万名儿童）。在同期未接种疫苗的246,600名儿童中，166名患上了糖尿病（相当于每年20.6/十万名儿童）。不完全接种（遗漏了一次或多次剂量）与糖尿病发病率不相关。

2006年至2017年使用了两种轮状病毒疫苗，一种是预防五种不同类型轮状病毒的五价疫苗，一种是预防一种轮状病毒的单价疫苗。接种了其中任意一种疫苗的儿童与未接种的儿童相比，前者因轮状病毒感染而住院的比率比后者低94%。在接种疫苗后的60天内，前者的整体住院率也较后者低31%，这表明疫苗是安全的。完全接种三个剂量的五价疫苗使I型糖尿病的风险降低了37%。

过去的人类及动物研究已将轮状病毒感染与I型糖尿病、β细胞损伤和胰腺感染联系起来。虽然还需要开展进一步的研究来详细探索接种轮状病毒疫苗与I型糖尿病风险下降之间的关联，但是作者认为接种轮状病毒疫苗可能是一种可以帮助预防I型糖尿病的可行措施。

摘要：We evaluated whether rotavirus vaccination is associated with the incidence of type 1 diabetes among children. We designed a cohort study of 1,474,535 infants in the United States from 2001–2017, using data from a nationwide health insurer. There was a 33% reduction in the risk of type 1 diabetes with completion of the rotavirus vaccine series compared to the unvaccinated (95% CI: 17%, 46%). Completion of the pentavalent vaccine series was associated with 37% lower risk of type 1 diabetes (95% CI: 22%, 50%). Partial vaccination (incompletion of the series) was not associated with the incidence of type 1 diabetes. There was a 31% reduction in hospitalizations in the 60-day period after vaccination (95% CI: 27%, 35%) compared to unvaccinated children. Overall, there was a 3.4% decrease in incidence annually in children ages 0–4 in the United States from 2006–2017 which coincides with the vaccine introduction in 2006. We conclude that rotavirus vaccination is associated with a reduced incidence of type 1 diabetes. Rotavirus vaccination may be the first practical measure that could play a role in the prevention of this disease.

阅读论文全文请访问：

期刊介绍： () is an online, open access journal from the publishers of Nature. We publish scientifically valid primary research from all areas of the natural and clinical sciences.

The 2017 journal metrics for Scientific Reports are as follows:

•2-year impact factor: 4.122

•5-year impact factor: 4.609

•Immediacy index: 0.576

•Eigenfactor® score: 0.71896

•Article Influence Score: 1.356

•2-year Median: 2

（来源：明升手机版(明升中国)）