论文标题：Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration

期刊：Scientific Reports

作者：Martin S. Zinkernagel, Denise C. Zysset-Burri, Irene Keller, Lieselotte E. Berger, Alexander B. Leichtle, Carlo R. Largiadèr, Georg M. Fiedler & Sebastian Wolf

发表时间： 2017/01/17

数字识别码：doi: 10.1038/srep40826

原文链接：

《app手机版》期刊发表的一项研究Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration描述了老年性黄斑变性（Age-related macular degeneration, 简称AMD）与肠道菌群组成和功能之间的关系。

图一：老年性黄斑变性患者与健康人群的肠道菌群对比。

Martin S. Zinkernagel et al.

AMD是老年人失明最常见的原因之一。有证据表明，营养、炎症和遗传背景是导致AMD产生的重要因素。最近的研究发现肠道微生物因为对炎症和宿主代谢有调控作用，会对代谢性疾病有影响。

为了探测肠道菌群的组成和功能是否和AMD有关，瑞士伯恩大学的Martin S. Zinkernagel和同事对AMD患者和健康人群的肠道宏基因组进行测序。他们发现AMD患者肠道中厌氧棍状菌属、颤杆菌属、扭链瘤胃球菌和凸腹真杆菌比例增加，而健康人群肠道中埃氏拟杆菌数量相对较多。患者的肠微生物在L-丙氨酸发酵，谷氨酸降解和精氨酸生物合成的途径上被发现会逐渐增多，而在脂肪酸合成的途径上则逐渐减少。

这些发现表明肠道菌群改变和AMD具有相关性，这意味着未来调整肠道微生物可能成为辅助治疗AMD的新方法。

摘要：Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly. There is evidence that nutrition, inflammation and genetic risk factors play an important role in the development of AMD. Recent studies suggest that the composition of the intestinal microbiome is associated with metabolic diseases through modulation of inflammation and host metabolism. To investigate whether compositional and functional alterations of the intestinal microbiome are associated with AMD, we sequenced the gut metagenomes of patients with AMD and controls. The genera Anaerotruncus and Oscillibacter as well as Ruminococcus torques and Eubacterium ventriosum were relatively enriched in patients with AMD, whereas Bacteroides eggerthii was enriched in controls. Patient’s intestinal microbiomes were enriched in genes of the L-alanine fermentation, glutamate degradation and arginine biosynthesis pathways and decreased in genes of the fatty acid elongation pathway. These findings suggest that modifications in the intestinal microbiome are associated with AMD, inferring that this common sight threatening disease may be targeted by microbiome-altering interventions.

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