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北京时间8月27日晚八点，iCANX Youth Talks第七十期邀请到了中山大学公共卫生学院副教授王琼，北京理工大学管理学院教授张弛，瑞典体育与健康大学及卡罗林斯卡明升手机版院副教授王瑞三位教授主讲，北京航空航天大学计算机学院副教授程健作为研讨嘉宾，北京理工大学管理学院教授张弛担任主持人，期待你一起加入这场知识盛宴。

【嘉宾介绍】

王琼

中山大学

气候变化背景下环境危害因素与明升m88早期健康

【Abstract】

Environmental risk factors related to global climate change threaten human health through various direct and indirect pathways. Due to their unique physiological and metabolic conditions, pregnant women and fetuses are especially vulnerable to these environmental risks. According to the developmental origins of health and disease (DOHaD) theory, early-life exposure to adverse environmental conditions can not only increase the risk of adverse birth outcomes but also impact the health of offspring later in life. We identified extreme temperatures (including both extremely high and low temperatures, as well as heatwaves) and air pollution as significant factors affecting birth outcomes, and quantitatively estimated their effects. By constructing exposure-lag-response relationship models, we pinpointed the critical gestational weeks during which exposure to these environmental factors impacts birth outcomes. Additionally, we explored the social determinants and biological mechanisms through which these exposures influence birth outcomes.

全球气候变化背景下，不利的环境因素可通过一系列直接或间接的路径对人群健康产生广泛而复杂的影响。由于特殊的生理和代谢状况，孕妇和胎儿极易受到外界环境危险因素的影响，是气候变化的高度脆弱人群。而根据健康和疾病的发育起源学说（developmental origins of health and disease，DOHaD），明升m88早期不良环境因素暴露，不仅危害孕妇健康和增加不良出生结局风险，还会增加子代儿童期和成年后罹患慢性疾病的几率。我们开展了气候变化相关环境因素暴露对明升m88早期健康的影响研究，首先识别了极端气温（极端高温、极端低温和高温热浪）和空气污染是影响妊娠结局的不利环境因素，并定量估计了其健康危害效应；然后通过构建暴露-滞后-反应关系模型，揭示了极端气温和空气污染暴露影响出生结局的关键孕周；此外，初步探讨了极端温度和空气污染物暴露影响胎儿发育和新生儿健康的社会驱动因素和生物学机制。

【BIOGRAPHY】

Dr. Qiong Wang is an Associate Professor at the School of Public Health, Sun Yat-sen University, and serves on the editorial boards of Advances in Climate Change Research and the Journal of Environmental Hygiene. Her research focuses on assessing health effects and risk management related to climate change. Dr. Wang has led several projects funded by the National Natural Science Foundation of China, Key Research and Development Programs from the Ministry of Science and Technology, and projects supported by the Guangdong Provincial Natural Science Foundation. She has published over 60 peer-reviewed papers in journals such as Nature Medicine, Environmental Health Perspectives, The Lancet Regional Health - Western Pacific, Environment International, and Epidemiology. Her research findings have been cited by The New England Journal of Medicine, Nature Reviews Cardiology, and the IPCC AR6, among others. Dr. Wang also co-edited the book Methods and Applications of Health Risk Assessment for Climate Change.

王琼，中山大学公共卫生学院副教授，博士生导师。担任Advances in Climate Change Research、环境卫生学杂志编委。主要研究方向为气候变化健康效应评估与风险管理。主持和参与国家科技部重点研发计划、广东省自然app基金面上项目、广东省科技厅项目等。近年来，在Nature Medicine, Environmental Health Perspectives, Lancet Regional Health West Pacific, Environment International, Epidemiology等国际权威期刊共发表了SCI论文60余篇。研究结果被The New England Journal of Medicine, Nature Reviews Cardiology等顶尖期刊和IPCC AR6等国际权威手机版引用。联合主编《气候变化健康风险评价方法与应用》专著一部，参与编写中英文教材和专著9部。

张弛

北京理工大学

气候变化对明升中国劳动生产率和安全户外活动的影响及适应措施研究【ABSTRACT】

The health risks associated with climate change are escalating, increasing the frequency and intensity of extreme weather events. Numerous regions have experienced record-high temperatures in China, with the national average temperature rising to the second highest in history, while precipitation levels have dropped to their lowest since 2012. Timely and adequate measures can mitigate climate changes health impacts and reduce economic losses for vulnerable populations and nations. Therefore, it is crucial to prioritize the health-related implications and their broader effects in addressing climate change. This study primarily evaluates the risks associated with high temperatures due to climate change on human activities (work and outdoor activities) in China and examines the effectiveness of adaptive measures in mitigating these risks. Climate change is considered to increase economic costs by worsening heat-related labor productivity loss and unsafe outdoor activities. While extensive global and national research has been conducted on this topic, few studies have analyzed subnational and individual economic impacts, potentially weakening local governments’ motivation to tackle climate change. Figuring out the most affected regions and vulnerable groups could help climate policymakers to identify priority regions and sectors to allocate adaptation resources efficiently, and enhance stakeholder engagement. This study adopted a provincial Computable General Equilibrium model by distinguishing different labors and regions in modelling work to address the aforementioned gap. The study estimated economic costs at different levels under three climate change scenarios (lower (SSP126), middle (SSP245), and higher (SSP585) warming scenario). This study also tracked the number of safe physical activity hours lost per capita per day at the provincial level when a heat index, which combines temperature and humidity, exceeded a threshold of 33 degrees.

气候变化带来的健康风险与日俱增，极端天气事件发生的频率和强度不断上升，许多地区气温记录屡创新高，全国平均气温攀升至历史第二高位，同时降水量自2012年以来创新低。采取及时、充分的措施不仅能减轻气候变化对健康的影响，还将减缓个体（脆弱人群）与国家的经济损失。因此，在应对气候变化的过程中，更应优先考虑健康问题的关联和影响。本研究将主要评估气候变化中高温对明升中国人群活动（工作和户外运动）的相关风险及其适应措施的改善效果。气候变化被认为通过加剧与高温相关的非安全户外活动时间以及劳动生产力损失而增加健康风险和经济成本。虽然在全球和国家层面上已经进行了一些相关研究，但针对次地方层面和个人经济影响的研究较少，找出受影响最严重的地区和脆弱人群，可以帮助气候政策制定者确定优先资源分配的区域和行业，提高利益相关方的参与度。在此次手机版中，采用了省级可计算一般均衡模型，通过在模型中区分不同的劳动者和地区，来填补上述研究空白。研究在三种气候变化情景（低（SSP126）、中（SSP245）和高（SSP585）升温情景）下估算了不同层级的劳动力生产经济成本与户外安全活动时间损失及其可行适应措施的效果评估。同时评估不同省份每人每天损失的安全体育活动小时数。

【BIOGRAPHY】

Chi Zhang is the Assistant Dean and Professor of the School of Global Governance and a Professor of the School of Management at the Beijing Institute of Technology. She is the associate editor of Applied Energy (IF 11.2), the vice-director of Lancet Countdown Asia Center, and the editorial board member of Environmental Research Letters (IF 6.9). She is an expert consultant of UNDP for training and empowering youth to achieve SDGs. Chi is the recipient of the Overseas High-level Talent Youth Programm in China, and iCANX Young Scientist Award. She teaches, advises, and conducts research on the impacts of climate change and energy transition on health and economy, energy management for renewable energy systems, carbon emission accounts and trading, sustainable development, and global governance with the digital economy. Over 30+ peer-reviewed papers have been published (IF 500+), including contributions to prestigious journals such as the Lancet Public Health, Nature, Applied Energy, Journal of Environmental Management, Energy Conversion and Management, etc. She has performed high-level research projects for the National Key Research and Development Program and NSFC in China, the Swedish Agency for Economic and Regional Growth, and the Swedish International Development Cooperation Agency in Sweden. Chi earned her BA in Economics from Peking University, MS in Economics from Stockholm University, and PhD in Energy Processes Management from the Royal Institute of Technology, Sweden.

张弛，北京理工大学管理学院教授，博士生导师，北京理工大学国际组织创新学院院长助理；兼任SCI一区期刊Applied Energy（IF11.2）副主编、柳叶刀倒计时亚洲中心副主任、SCI一区期刊Environmental Research Letters (IF 6.9)编委；联合国发展署（UNDP）可持续发展目标青年赋能项目专家顾问。iCANX青年app家。主要研究方向为气候变化能源转型的健康影响及经济评估、能源环境经济与管理，碳减排核算与交易，可持续发展与全球治理。已在国内外期刊发表学术论文30余篇，影响因子总计500+，相关成果以第一作者及通讯作者发表在包括Lancet Public Health(5篇), Applied Energy, Journal of Environmental Management, Energy Conversion and Management等在内的国际顶级期刊上，主持并参与多个国家自然app基金，相关工作曾得到多项国际app研究基金支持。张弛分别在北京大学获得经济学学士学位，斯德哥尔摩大学获得经济学硕士学位，瑞典皇家理工学院获得能源过程管理博士学位。

王瑞

瑞典体育与健康大学及卡罗林斯卡明升手机版院

多维度生活方式的改变与老年人健康

【ABSTRACT】

As global aging accelerates, the health of older populations has gained widespread attention across society. Dementia, especially Alzheimers disease (AD), is widely recognized as a multifactorial condition associated with aging. The 2024 update from the Lancet Commission on dementia highlights that nearly half of all dementia cases worldwide could be prevented or delayed by targeting 14 modifiable risk factors. Identifying these risk factors and biomarkers has thus become a critical goal in dementia research, aiming to enable the early prevention and diagnosis of AD and other age-related diseases.In this report, I will first discuss the epidemiological risk factors for AD and then introduce current global research on multidomain lifestyle interventions, with a particular focus on the FINGER study. Next, I will present the latest findings from the MIND-AD study, which emphasizes multidomain lifestyle interventions in patients with prodromal AD. Finally, I will explore the shared lifestyle risk factors between AD and ischemic stroke.

随着全球老龄化的加剧，老年人健康已成为社会日益关注的焦点。作为一种与老龄密切相关的疾病，老年痴呆已被广泛认为是由多种危险因素共同作用所引发的疾病。2024年《柳叶刀》关于痴呆预防、干预和护理的常设委员指出，通过应对14个可改变的风险因素，全球近一半的痴呆病例可以被预防或延缓。通过识别相关危险因素和生物标志物，实现老年痴呆及其他与年龄相关疾病的早期预防和早期诊断，是老龄app研究者的共同目标。在本手机版中，我将首先探讨老年痴呆的流行病学危险因素，随后介绍当前全球范围内有关老年痴呆多维度生活方式干预的研究，特别是FINGER研究。接下来，我将介绍最新的MIND-AD研究，重点讨论在早期痴呆患者中进行的多维度生活方式干预。最后，我将讨论阿尔茨海默病与缺血性中风之间的共同生活方式风险因素。

【BIOGRAPHY】

Rui WANG, Associate Professor at the Swedish School of Sport and Health Sciences and Karolinska Institute. She received the undergraduate degree in Preventive Medicine from Shandong University and completed her Masters degree in Biostatistics at the same institute in 2007. In September 2015, she received her Ph.D. from the Aging Research Center at Karolinska Institute, Sweden. From 2018 to 2020, she had her postdoctoral fellow at the Wisconsin Alzheimers Disease Research Center, University of Wisconsin-Madison, funded by the Swedish Research Council. To date, she has published over 50 articles in high-impact international journals, including Alzheimer’s & Dementia, Neurology, and JAMA Neurology. Her research group currently focuses on mechanisms and prevention related to body-heart-brain connections, as well as using wearable devices to detect early symptoms of dementia.

王瑞，现任瑞典体育与健康大学及卡罗林斯卡明升手机版院副教授、博士生导师。她于2007年在山东大学公共卫生学院获得预防明升手机版本科，并于2010年在同校获得卫生统计学硕士学位，于2015年9月在瑞典卡罗林斯卡明升手机版院老年研究中心获得博士学位。在2018年至2020年间，她在瑞典app基金委资助下，于美国威斯康星大学麦迪逊校区的阿尔茨海默病研究中心从事博士后研究。迄今为止，她在《Alzheimer’s & Dementia》、《Neurology》和《JAMA Neurology》等高水平国际期刊上发表了50余篇论文。她的研究团队目前主要致力于身心脑途径的机制研究和预防工作，并利用可穿戴设备捕捉老年痴呆的早期症状。

【主持人】

张弛

北京理工大学

【研讨嘉宾】

程健

北京航空航天大学