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北京时间2024年3月29日晚八点，iCANX Talks 第179期邀请到了北卡罗来纳州立大学Xiaoning Jiang教授进行分享！此外，北京航空航天大学Jianguo Ma，仁荷大学Howuk Kim，北京大学Mengdi Han三位教授担任嘉宾，北京大学Ji Wan博士作为挑战者，北京大学Haixia Zhang教授担任主持人。

【嘉宾介绍】

Xiaoning Jiang

北卡罗来纳州立大学

Toward Precision Biomedical Ultrasound

【Abstract】

In recent years, there has been a remarkable advancement in biomedical ultrasound technology, particularly in the field of miniaturized transducers. These innovations have paved the way for precise and minimally invasive diagnosis and treatment of increasingly concerned diseases such as cardiovascular disease (CVD) and cancer. In this talk, micro/nanotechnology enabled small aperture ultrasound transducers were designed, fabricated and tested for precision biomedical ultrasound imaging, therapy and drug delivery. In specific, we investigated high frequency transducers for advanced intravascular ultrasound (IVUS) imaging. Small aperture forward-looking and vortex transducers were successfully demonstrated in-vitro for effective microbubbles and nanodroplets mediated intravenous sonothrombolysis. Moreover, miniaturized transducers enabled sonoporation was successful in enhancing localized drug delivery. These new findings suggest that precision biomedical ultrasound via minimal invasion can be significant in advanced ultrasound imaging, therapy, and drug delivery for unprecedented disease diagnosis and treatment.

近年来，生物明升手机版超声技术取得了显着的进步，特别是在小型化换能器领域。这些创新为心血管疾病（CVD）和癌症等日益受到关注的疾病的精确和微创诊断和治疗铺平了道路。在本次演讲中，我将手机版用于精密生物明升手机版超声成像、治疗和药物输送，基于微/纳米技术的小孔径超声换能器的设计、制造和测试。具体来说，我们研究了用于先进血管内超声 (IVUS) 成像的高频换能器。小孔径前视和涡流换能器已在体外成功证明可用于有效的微泡和纳米液滴介导的静脉超声溶栓。此外，微小型换能器实现的声孔作用可以显著增强局部药物输送。这些新发现表明，通过微创实现的精准生物明升手机版超声在先进超声成像、治疗和药物输送方面具有重要意义，可帮助实现前所未有的疾病诊断和治疗。

【BIOGRAPHY】

Xiaoning Jiang is the Dean F. Duncan Distinguished Professor of Mechanical and Aerospace Engineering and a University Faculty Scholar at North Carolina State University. He is also an Adjunct Professor of Biomedical Engineering at North Carolina State University and University of North Carolina, Chapel Hill, and an Adjunct Professor of Neurology in Duke University. Dr. Jiang received his Ph.D. degree from Tsinghua University (1997) and his Postdoctoral training from the Nanyang Technological University (1996-1997) and the Pennsylvania State University (1997-2001). He was the Chief Scientist and Vice President for TRS Technologies, Inc. prior to joining NC State in 2009. Dr. Jiang is the author and co-author of two books, 6 book chapters, 11 issued US Patents, more than 180 peer reviewed journal papers and over 140 conference papers on piezoelectric ultrasound transducers, ultrasound for medical imaging and therapy, drug delivery, ultrasound NDT/NDE, smart materials and structures and M/NEMS. Dr. Jiang served as the Vice President for Technical Activities in IEEE Nanotechnology Council (NTC) (2022-2023). He was the Co-Editor-in-Chief of IEEE Nanotechnology Magazine (2020 - 2021) and an IEEE NTC Distinguished Lecturer in 2018-2019. Dr. Jiang is an ASME Fellow, a SPIE Fellow and an IEEE Fellow.

江小宁是北卡罗来纳州立大学机械与航空航天工程系 Dean F. Duncan 杰出教授、大学教员学者。他还是北卡罗来纳州立大学和北卡罗来纳大学教堂山分校的生物明升手机版工程兼职教授，以及杜克大学神经病学兼职教授。江博士于1997年获得清华大学博士学位，在南洋理工大学（1996-1997）和宾夕法尼亚州立大学（1997-2001）进行博士后研究。在 2009 年加入北卡罗来纳州立大学之前，他曾担任 TRS Technologies, Inc. 的首席app家兼副总裁。江博士与合作者发表了有关压电超声换能器、超声明升手机版成像和治疗、药物输送、超声 无损检测、智能材料和结构以及 M/NEMS的书籍（2）、书籍章节（6），11 项美国专利、180 多项同行评审期刊文章和140 多篇会议论文。江博士曾担任 IEEE 纳米技术委员会（NTC）技术活动副总裁（2022-2023）。他曾担任 IEEE 纳米技术杂志联合主编（2020-2021 年），并于 2018-2019 年担任 IEEE NTC 杰出讲师。